Sodium butyrate (Topical Term)

Work cat: Saldanha, S.N. Genetic and epigenetic changes regulated by bioactive molecules in cancer therapeutics, 2014: abstr. (The aim of this dissertation was to determine the effectiveness of epigallocatechin-3-gallate (EGCG) and sodium butyrate (NaB) as epigenetic modulators against CRCs [colorectal cancers])

Anticancer research, Sept.-Oct. 2007: p. 3286 (Sodium butyrate is a short-chain fatty acid that is generated from the fermentation of dietary fiber by anaerobic bacteria in the lumen of the intestine. It is also present in fruits, vegetables and milk fat. Sodium butyrate may induce cell cycle arrest and apoptosis. The effect of sodium butyrate might result from its function as an HDAC inhibitor)

Diabetes, July 2009: p. 1509 (Butyric acid has four carbons in the molecule (CH3CH2CH2-COOH) and becomes sodium butyrate after receiving sodium. Sodium butyrate is a dietary component found in foods such as cheese and butter. It is also produced in large amounts from dietary fiber after fermentation in the large intestine, where butyric acid is generated together with other short-chain fatty acids from nondigestible carbohydrates, such as nonstarch polysaccharides, resistant starch, and miscellaneous low-digestible saccharides. The bioactivities of sodium butyrate are related to inhibition of class I and class II histone deacetylases)

FASEB journal, Nov. 1999: p. 1991 (The histone deacetylase inhibitor and potential anti-cancer drug sodium butyrate is a general inducer of growth arrest, differentiation, and in certain cell types, apoptosis. In human CCRF-CEM, [i.e.] acute T lymphoblastic leukemia cells, butyrate, and other histone deacetylase inhibitors caused G2/M cell cycle arrest as well as apoptotic cell death)