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An introduction to medicinal chemistry /

By: Patrick, Graham L [author.].
Publisher: Oxford, United Kingdom : Oxford University Press, 2017Edition: 6th edition.Description: xxxi, 877 pages : illustrations 27 cm.Content type: text | text | still image Media type: unmediated | unmediated Carrier type: volume | volumeISBN: 9780198749691; 9780198749691:; 0198749694.Subject(s): Pharmaceutical chemistry | Chemistry, Pharmaceutical | Drug Design | PharmacokineticsDDC classification: 615.19
Contents:
Drugs and drug targets : an overview -- Protein structure and function -- Enzymes : structure and function -- Receptors : structure and function -- Receptors and signal transduction -- Nucleic acids : structure and function -- Enzymes as drug targets -- Receptors as drug targets -- Nucleic acids as drug targets -- Miscellaneous drug targets -- Pharmacokinetics and related topics -- Case study 1 : statins -- Drug discovery : finding a lead -- Drug design : optimizing target interactions -- Drug design : optimizing access to the target -- Getting the drug to market -- Case study 2 : the design of ACE inhibitors -- Case study 3 : artemisinin and related antimalarial drugs -- Case study 4 : the design of oxamniquine -- Combinatorial and parallel synthesis -- Computers in medicinal chemistry -- Quantitative structure-activity relationships (QSAR) -- Case study 5 : design of a thymidylate synthase inhibitor -- Antibacterial agents -- Antiviral agents -- Anticancer agents -- Cholinergics, anticholinergics, and anticholinesterases -- Drugs acting on the adrenergic nervous system -- The opioid analgesics -- Anti-ulcer agents -- Cardiovascular drugs -- Case study 6 : steroidal anti-inflammatory agents -- Case study 7 : current research into antidepressant agents -- Case study 8 : the design and development of aliskiren -- Case study 9 : factor Xa inhibitors -- Case study 10 : reversible inhibitors of HCV NS3-4A protease -- Appendix 1 : essential amino acids -- Appendix 2 : the standard genetic code -- Appendix 3 : statistical data for QSAR -- Appendix 4 : the action of nerves -- Appendix 5 : microorganisms -- Appendix 6 : trade names and drugs -- Appendix 7 : hydrogen bonding interactions.
Summary: Providing an introduction to medicinal chemistry, this resource covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
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Holdings
Item type Current library Call number Status Date due Barcode Item holds
Standard Loan Standard Loan ATU Sligo Yeats Library Main Lending Collection 615.19 PAT (Browse shelf(Opens below)) Available 0063260
Total holds: 0

Includes appendices, bibliographical references and index.

Drugs and drug targets : an overview -- Protein structure and function -- Enzymes : structure and function -- Receptors : structure and function -- Receptors and signal transduction -- Nucleic acids : structure and function -- Enzymes as drug targets -- Receptors as drug targets -- Nucleic acids as drug targets -- Miscellaneous drug targets -- Pharmacokinetics and related topics -- Case study 1 : statins -- Drug discovery : finding a lead -- Drug design : optimizing target interactions -- Drug design : optimizing access to the target -- Getting the drug to market -- Case study 2 : the design of ACE inhibitors -- Case study 3 : artemisinin and related antimalarial drugs -- Case study 4 : the design of oxamniquine -- Combinatorial and parallel synthesis -- Computers in medicinal chemistry -- Quantitative structure-activity relationships (QSAR) -- Case study 5 : design of a thymidylate synthase inhibitor -- Antibacterial agents -- Antiviral agents -- Anticancer agents -- Cholinergics, anticholinergics, and anticholinesterases -- Drugs acting on the adrenergic nervous system -- The opioid analgesics -- Anti-ulcer agents -- Cardiovascular drugs -- Case study 6 : steroidal anti-inflammatory agents -- Case study 7 : current research into antidepressant agents -- Case study 8 : the design and development of aliskiren -- Case study 9 : factor Xa inhibitors -- Case study 10 : reversible inhibitors of HCV NS3-4A protease -- Appendix 1 : essential amino acids -- Appendix 2 : the standard genetic code -- Appendix 3 : statistical data for QSAR -- Appendix 4 : the action of nerves -- Appendix 5 : microorganisms -- Appendix 6 : trade names and drugs -- Appendix 7 : hydrogen bonding interactions.

Providing an introduction to medicinal chemistry, this resource covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.

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